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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painusing a dose-escalative, randomized, placebo-controlled trial design. We also examined the effect of steroids on pain intensity, function and safety. Methods: Our search was conducted using relevant databases (PubMed, Ovid Medline, CINAHL and Embase) and a comprehensive keyword search in each of the following key terms: musculoskeletal pain, systemic corticosteroids, oral corticosteroids, NSAID, NSAID with NSAID therapy, glucocorticoids, glucocorticoids plus corticosteroids, glucocorticoids plus non-steroidal anti-inflammatory drug (NSAID) therapy, pain intensity, function and safety, steroids buy aus. We also searched the Cochrane Library and the Cochrane Central Register of Controlled Trials. If more than one study was found, the most relevant to both groups was used. Study Selection: All studies of corticosteroid injections or NSAIDs were included if they were performed in healthy individuals, steroidscanada com review. Studies using either corticosteroids (alone or in combination with acetaminophen, ibuprofen and aspirin) or NSAIDs (alone or in combination with ibuprofen and aspirin) for an inflammatory disorder, were also included. Only randomised controlled trials of either corticosteroids or NSAIDs were considered. Data Extraction: A study was classified according to the criteria provided by Kuyken et al, steroids buy greece.14 (see the article on inclusion and exclusion criteria) If no study with appropriate study criteria was found after screening, a search of the relevant databases was performed before inclusion (PubMed, Ovid Medline, CINAHL and Embase) with the keywords: musculoskeletal pain, non-steroidal anti-inflammatory drug (NSAID), systemic corticosteroids, corticosteroids with acetaminophen, corticosteroids plus acetaminophen, glucocorticoids, glucocorticoids plus corticosteroids, glucocorticoids plus non-steroidal anti-inflammatory drug (NSAID) therapy, pain intensity, function and safety, steroids buy greece. Data Analysis: We used random-effects mixed design with random-sequence generation and all variables were included simultaneously. We evaluated the association between injection of corticosteroid or NSAID or non-steroidal anti-inflammatory drug with pain outcomes based on the primary objective outcome variable: pain intensity at six-month follow-up.
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